Ph.D., Professor, Executive Director of
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological
Sciences, Chinese Academy of Sciences (CAS). He was graduated from the
Department of Biology, Nanjing University in 1983 and commenced Ph.D. in 1989
at former Shanghai Institute of Biochemistry, CAS. From 1990 to 1992 he worked
as a postdoctoral research associate at Department of Physiology and
Biophysics, SUNY at Stony Brook. He was appointed as associate professor by
Shanghai Institute of Biochemistry in 1991, and then professor in 1993. He has
for years focused on the study of the mechanisms of enzyme catalysis and
regulation. The main project was stucture/function of a bifunctional enzyme,
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Now his laboratory mainly
focuses on the mechanisms of signal transduction, including Wnt pathway and G
protein-coupled receptor mediated signaling.
Recent Publications (Selected)£º
1. Lin Li*, Junhao Mao, Le Sun, Wenzhong Liu & Dianqing Wu£¨2002£©Second
cysteine-rich domain of dickkopf-2 activates canonical Wnt signaling pathway
via LRP-6 independently of disheveled. J. Biol. Chem., 277, 5977-5981.
2. Junhao Mao, Jiyong Wang, Bo Liu, Weijun Pan, Gist H. Farr III, Christopher
Flint, Huidong Yuan, Shinji Takada, David Kimelman, Lin Li* & Dianqing Wu*
(2001) Low-density lipoprotein receptor-related protein-5 binds to Axin and
regulates the canonical Wnt signaling pathway. Mol. Cell, 7, 801-809. (*
Corresponding authors)
3. Qi-Heng Yang, Zheng Zhu, Meng-Qiu Dong, Song Ling, Chun-Lai Wu & Lin Li
(2001) Binding of ATP to the fructose-2,6-bisphosphatase domain of chicken
liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase leads to activation
of its 6-phosphofructo-2-kinase. J. Biol. Chem., 276, 24608-24613.
4. Zheng Zhu, Song Ling, Qi-heng Yang & Lin Li (2001) Involvement of
chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase sequence
His444-Arg-Glu-Arg in modulation of the bisphosphatase activity by its kinase
domain. Biochem. J., 357, 513-520.
5. Xiao-qing Gan, Ji-yong Wang, Qi-heng Yang, Zhong Li, Feng Liu, Gang Pei
& Lin Li (2000) Interaction between the conserved region in the C-terminal
domain of GRK2 and rhodopsin is necessary for GRK2 to catalyze receptor
phosphorylation. J. Biol. Chem., 275, 8469-8474.
6. Zheng Zhu, Song Ling, Qiheng Yang & Lin Li (2000)The difference in the
Carboxy- terminal sequence is responsible for the difference in the activity of
chicken and rat liver fructose-2,6-bisphosphatase. Biol. Chem., 381, 1195-1202.
7. Hing C. Wong, Junhao Mao, Jason T. Nguyen, Shamala Srinivas, Weixing Zhang,
Bo Liu, Lin Li, Dianqing Wu & Jie Zheng (2000) Structural basis of the
recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat.
Struct. Biol., 7, 1178-1184.
8. Lin Li, Huidong Yuan, Carole D. Weaver, Junhao Mao, Gist H.Farr III, Daniel
J. Sussman, Jos Jonkers, David Kimelman & Dianqing Wu (1999) Axin and Frat1
interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of
LEF-1. EMBO J., 18, 4233-4240.
9. Lin Li, Huidong Yuan, Wei Xie, Junhao Mao, Ann M. Caruso, Andrew McMahon,
Daniel J. Sussman & Dianqing Wu (1999) Dishevelled proteins lead to two
signaling pathways: Regulation of LEF-1 and c-Jun N-terminal kinase in
mammalian cells. J. Biol. Chem., 274, 129-134.